UDK: 616.15:616.31

THE INFLUENCE OF SYNTHETIC INDOLICIDIN ANALOGUES ON THE HEMATOLOGICAL INDICES IN THE RATS WITH EXPERIMENTAL PERIODONTITIS

I.V. Kutepov 1, Y.D. Lyashev 1, M.A. Zatolokina 2

1 ФГАОУ ВО «Белгородский национальный исследовательский университет», кафедра фармакологии и клинической фармакологии; 2 ФГБОУ ВО «Курский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра гистологии, эмбр

Abstract

Synthetic analogues of indolicidin are considered as potential antibiotics, since they have a wide spectrum of antimicrobial activity. We used synthetic analogues of indolicidin No. 7 and 8, which were used to correct experimental periodontitis in Wistar rats. Peptides were injected intraperitoneally at a dose of 500 μg/kg for 7 days after periodontitis modeling. The anti-inflammatory effect of indolicidin analogues was assessed by changes in integral hematological indices. A statistically significant effect of the studied indolicidin analogues on the neutrophil-to-monocyte ratio and the leukocyte index was established, which indicates to the effect of peptides on the macrophage-monocytic cell pool, as well as the affector and effector mechanisms of the humoral immune response.

Keywords

periodontitis, indolicidn analogues, hematologic indices, anti-inflammatory effect.

Contacts

Кутепов Игорь Валериевич – соискатель кафедры фармакологии и клинической фармакологии Медицинского института, Белгородский национальный исследовательский университет, e-mail: kutepov-iv@yandex.ru