UDK: 615.256.2:616-031.38-005.4-085

EFFECT OF UDENAFIL ON THE COURSE OF EXPERIMENTAL CRITICAL ISCHEMIA OF THE LOWER EXTREMITIES

E.E. Feyziev 1, B.S. Sukovatykh 1, M.A. Zatolokina 1, A.S. Belous 2, E.V. Trubnikova 2

1 ФГБОУ ВО «Курский государственный медицинский университе» Министерства здравоохранения Российской Федерации; 2Научно-исследовательская лаборатория «Генетика», ФГБОУ ВО «Курский государственный университет»

Abstract

The paper shows a comparative assessment of the effect of udenafil (Zidena®, Dong-A Pharmaceutical Co. Ltd., Korea) on the perfusion of healthy and ischemic tissues in critical ischemia of the lower extremities simulated in rats. Formed 4 experimental groups: 1 – intact; 2 – healthy animals with the introduction of udenafil (orally 8,6 mg/kg for 28 days); 3 – animals with ischemia without treatment; 4 – animals with ischemia and monotherapy with udenafil (similar to group 2). On the 21st and 28th days in all groups, the level of blood microcirculation in the leg muscles was recorded. At the same time, 10 animals were withdrawn from the experiment by anesthesia overdose and histological preparations of the leg muscles were prepared. The results obtained showed that udenafil increases regional blood flow both in non-ischemic tissues and in critical ischemia of the lower extremities.

Keywords

critical lower limb ischemia, ischemia correction, udenafil, pharmacotherapy, phosphodiesterase-5, rats.

Contacts

Фейзиев Эльвин Эйнулла-оглы – соискатель кафедры общей хирургии, Курский государственный медицинкий университет, e-mail: elvin251546@gmail.com