UDK: 615.212.7:616.831-005-092.4

CEREBROPROTECTIVE ACTIVITY OF A NEW HYDRAZIDE DERIVATIVE OF 2-PYRROLIDONE UNDER CONDITIONS OF EXPERIMENTAL CHRONIC CEREBROVASCULAR INSUFFICIENCY

D.V. Kurkin 1, D.A. Bakulin 1, D.V. Verholyak 1, N.S. Kovalev 1, E.E. Abrosimova 1, M.A. Dubrovina 1, E.S. Ostroglyadov 2

1 ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации; 2 ФГБОУ ВО «Российский государственный педагогический университет им. А.И. Герцена»

Abstract

The effect of a new hydrazide derivative of 2-pyrrolidone on neuropsychiatric deficiency in animals with chronic cerebrovascular insufficiency after course administration was studied. The pathology was modeled by narrowing the lumen of the common carotid arteries to 50 %. The test substances began to be administered from the 40th day and continued for 14 days. The effectiveness of therapy was assessed by the severity of motor, coordination and sensory-motor disorders in animals, which were respectively determined in the tests: Open Field, Rotarod and Adhesive. Stenosis of the common carotid arteries was accompanied by impaired coordination and sensory-motor function. A new derivative of alpha-pyrrolidone improved coordination and sensory function in experimental animals. Cerebroprotective activity of the new derivative of 2-pyrrolidone was comparable to the reference drugs phenotropil and citicoline

Keywords

2-pyrrolidone, chronic cerebrovascular insufficiency, neuropsychological deficit, rats.

Contacts

Бакулин Дмитрий Александрович – к. м. н., доцент кафедры клинической фармакологии и интенсивной терапии, Волгоградский государственный медицинский университет, e-mail: mbfdoc@gmail.com