UDK: 615.038

STUDY OF SOME ASPETS NEUROPROTECTIVE ACTIVITY OF PHENYLACETIC ACID AMIDES UNDER CONDITIONS OF FOCAL BRAIN ISCHEMIA

M.V. Chernikov, A.V. Sosnovskaya, D. I. Pozdnyakov

Пятигорский медико фармацевтический институт филиал ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации

Abstract

The article presents the results of studying the neuroprotective activity of carboxylic acid diamides under conditions of focal cerebral ischemia. The study was carried out on male Wistar rats, which underwent focal ischemia by irreversible occlusion of the right middle cerebral artery. The compounds under study under the codes FacAc, FacPr, FisBut, Faib, the reference drug piracetam were injected intragastrically on the next day after the operation at a dose of 100 mg/kg and then for three days. The neuroprotective activity of the compounds was studied using models for assessing memory and cognitive functions the technique of avoiding passive (CPAR) and active (EMT) environments, and also studied the effect of compounds on the size of the necrosis zone. In the course of the study, it was found that, against the background of focal cerebral ischemia, the use of diamides of carboxylic acids contributed to the preservation of the memory trace in rats, as well as the necrosis zone. The results of experimental data indicate the possibility of further in-depth study of the compounds under study under laboratory codes FacAc, FacPr, FisBut, Faib for neuroprotective activity.

Keywords

ischemia, necrosis, phenylacetyc acid amides, piracetam.

Contacts

Поздняков Дмитрий Игоревич – к. фарм. н., доцент, кафедра фармакологии с курсом клинической фармакологии, Пятигорский медико фармацевтический институт филиал ФГБОУ ВО «Волгоградский государственный медицинский университет» Минздрава России, e mail: pozdni