UDK: 612.64:611.018

TYPE I EPITHELIAL-MESENCHYMAL TRANSITION AS AN IMPORTANT BIOLOGICAL PROCESS IN EMBRYOGENESIS

I.A. Dvoryashina1, Yu.I. Velikorodnaya2, A.V. Terentev1, V.L. Zagrebin1

1 ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра гистологии, эмбриологии, цитологии; 2 ГБУ «Волгоградский медицинский научный центр»

Abstract

Epithelial-mesenchymal (EMT) and mesenchymal-epithelial (MEP) transitions play a significant role in the processes of embryogenesis, organogenesis and cell differentiation. The epithelial-mesenchymal transition also promotes the regeneration of damaged tissues, but in the case of its aberrant activation, it can initiate and aggravate the course of pathological processes such as fibrosis, metastasis, and carcinogenesis. In this review, we described the history of the study of these processes in the context of embryonic development, and also discussed the problems of terminology and different views on the concept of the determinism of the pathway of mature cells.

Keywords

epithelial-mesenchymal transition, embryogenesis, mesenchyme, ectoderm.

Contacts

Дворяшина Ирина Александровна – старший преподаватель кафедры гистологии, эмбриологии, цитологии, Волгоградский государственный медицинский университет, e-mail: germionna@yandex.ru