UDK: 616.697-021.6

INFLUENCE OF GROWTH FACTORS ON SPERMATOGENESIS AFTER AIMED IRRADIATION OF RAT TESTES WITH ELECTRONS IN A DOSE OF 8 GRAY

G.A. Demyashkin1,2

1ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет), Москва; 2Медицинский радиологический научный центр им. А.Ф. Цыба – филиал «НМИЦ радиологии», г. Обнинск

Abstract

The morphological assessment of spermatogenesis using platelet-enriched plasma after electron irradiation at a dose of 8 Gray was studied. A week after irradiation, a sharp decrease in the number of germ cells was found; decrease in the area of the testis and the height of the spermatogenic epithelium; the appearance of seed balls. Positive effects after the application of LP-PRP + IGF were observed already in the third week, which persisted throughout the entire experiment. The growth factors of platelet-rich plasma in combination with IGF promote the activation of poorly differentiated spermatogonia and the restoration of the pool of germ cells after irradiation with the NOVAC-11 pulsed electron accelerator at a dose of 8 Gray.

Keywords

spermatogenesis, infertility, radiation, LP-PRP.

Contacts

Демяшкин Григорий Александрович – к. м. н., доцент кафедры патологической анатомии им. академика А.И. Струкова, Первый МГМУ им. И.М. Сеченова (Сеченовский Университет), e-mail: dr.dga@mail.ru