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HISTOLOGICAL AND IMMUNOHISTOCHEMICAL FEATURES OF BONE TISSUE AND RED BONE MARROW IN ACUTE HEMATOGENOUS OSTEOMYELITIS IN CHILDREN

A.G. Sirak, A.N. Grigorova, M.O. Didenko, M.A. Dolgashova, N.N. Didenko, E.I. Piskareva, E.I. Pashneva, O. G. Magomedova, A.P. Arutyunova

ФГБОУ ВО «Ставропольский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра гистологии

Abstract

Acute hematogenous osteomyelitis (AHO) is a severe disease of childhood and leads to disability in 70–87 % of cases. Despite the achievements of modern science, research methods are not always able to diagnose CSO in children in time. The number of scientific works devoted to the early diagnosis of CSO in children based on the use of morphological and functional characteristics of bone tissue is limited. The material for the study was a biopsy of bone tissue and red bone marrow obtained after osteoperforation in children with CSO. After preliminary processing of the biopsy, histological and immuno-histochemical studies were performed, followed by an assessment of the prognostic value of the data obtained. The study revealed histological changes in bone tissue characteristic of the intramedullary and extramedullary phases of CSO, IHC indicators of an increase in the population of cytotoxic T-lymphocytes in the red bone marrow, indicating the development of a severe inflammatory process.

Keywords

hematogenous osteomyelitis, acute inflammation, T-lymphocytes, immunohistochemical reaction, children.

Contacts

Сирак Алла Григорьевна – д. м. н., профессор, зав. кафедрой гистологии, Ставропольский государственный медицинский университет, e-mail: sergejsirak@yandex.ru