UDK: 615.2.03: 616.1

QUANTITATIVE ASSESSMENT OF OPTIONS FOR THE USE OF SINGLE-COMPONENT ANTIHYPERTENSIVE DRUGS AT VARIOUS STAGES OF THE INTENSIFICATION OF HYPERTENSION THERAPY

S.V. Nedogoda1, A.V. Sabanov1, A.S. Salasyuk1, V.O. Lutova1, E.A. Popova1, O.I. By hkova2, M.V. Rubtsova1

1ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра внутренних болезней института НМФО; 2Военно-медицинская служба УФСБ России по Волгоградской области

Abstract

In hypertension, the administration of several single-component antihypertensive drugs from different groups increases the choice of pharmacotherapy options. Conducted a quantitative assessment of these options at various stages of intensification of antihypertensive therapy. The international nonproprietary name, trade name and dosage of the drugs were taken into account. The methods of combinatorics were used for the calculation. At each stage of the intensification, the number of possible combinations of drugs increased significantly, which could eventually reach 1 834 555 464. The obtained results revealed the problem of choosing rational antihypertensive therapy during its intensification, which is the justification for the development of a specialized decision support system.

Keywords

arterial hypertension, intensification of antihypertensive therapy, use methods of combinatorics.

Contacts

Сабанов Алексей Валерьевич – д. м. н., профессор кафедры внутренних болезней института НМФО, Волгоградский государственный медицинский университет, e-mail: sabanov@yandex.ru