UDK: 612.017.1:576.3

EFFECT OF CHRONIC STRESS ON PRIMARY AND SECONDARY LYMPHOID ORGANS OF RATS AND ITS REVERSIBILITY DEPENDING ON THE DURATION OF STRESS EXPOSURE

N. A. Muraeva, T.S. Smirnova, O.V. Fedorova, Yu.A. Tkachenko, L.V. Vondrachek

ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра гистологии, эмбриологии, цитологии

Abstract

The influence of chronic stress on the lymphoid organs and its reversibility depending on the duration of exposure was studied. Male rats were subjected to stress – restricted movement and forced swimming daily for 2, 4 and 8 weeks. After each exposure period, the rats were allowed to recover for 6 weeks. Stress exposure led to a decrease in the mass of the thymus and axillary lymph nodes, the number of spleen lymphocytes, thymus and axillary lymph nodes, and an increase in the apoptotic index of splenocytes, thymocytes and lymphocytes of axillary lymph nodes, depending on its duration. The thymus was the most stress-sensitive lymphoid organ. After 2 and 4 weeks of stress exposure, the spleen parameters and most of the parameters of the thymus and axillary lymph nodes in rats returned to the control level after recovery, but not in the group with 8 weeks of stress exposure. The severity of stress on the lymphoid organs increases with the duration of exposure, and with a shorter period of exposure, recovery occurs faster.

Keywords

corticosterone, lymphoid organs, reversibility, spleen, thymus, axillary lymph nodes, stress.

Contacts

Мураева Наталья Алексеевна – к. м. н., доцент, доцент кафедры гистологии, эмбриологии, цитологии, Волгоградский государственный медицинский университет, e-mail: natalia.muraewa@yandex.ru