UDK: 618.11-006:616-018
E.S. Gozman, N.A. Makarova
ФГБОУ ВО «Кировский государственный медицинский университет» Минздрава России, г. Киров
The relevance of the work lies in the fact that for the first time the information on the distinctive markers of borderline ovarian tumors has been generalized. Based on the analysis of literature data, three groups of markers were identified: histological, genetic, immunohistochemical. The article describes the features of the histological structure of these tumors and presents various informative criteria for borderline ovarian tumors: genetic – BRAF, KRAS, PTEN, p53, immunohistochemical – ITGA2, OPN, and TSP1. Were also described immunohistochemical markers of proliferative activity – Ki-67, CK-20. The use of these markers in clinical practice makes it possible to carry out differential diagnostics of tumors, as well as to predict the course of the disease.
ovarian tumor, borderline ovarian tumor, histology, genetics, immunohistochemistry.
Гозман Елена Сергеевна – аспирант кафедры гистологии, эмбриологии и цитологии ФГБОУ ВО Кировский ГМУ Минздрава России, e-mail: alenablumari@yandex.ru