UDK: 615.214.2:547.856.1:616.831-005.1-092.4

CEREBROPROTECTIVE ACTIVITY OF QUINAZOLINE-4(3H)-ONE DERIVATIVES WITH A GUANIDINE SUBSTITUENT IN RATS WITH BILATERAL COMMON CAROTID ARTERY OCCLUSION

A.V. Borisov2,5, E.V. Volotova1, A. . Ozerov3,4, D.V. Kurkin2, D.A. Bakulin2, E.E. Abrosimova1, L.E. Borodkina1, J.A. Smolnyakova1

ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, Волгоград 1кафедра фармаколог

Abstract

From derivatives of quinazolin-4 (3H) -one, 2 substances were isolated: VMA-13-15 (N-[2-[4-oxo-3(4H)-quinazolinyl] propionyl]guanidine) and VMA-13-17 (N-[2-[6-bromo-4-oxo-3(4H)-quinazolinyl]acetyl]guanidine). With the therapeutic administration of the compounds, the survival rate and neurological condition of animals with bilateral occlusion of the common carotid arteries were better than in the control group. Also 72 hours after surgery and treatment, the level of cerebral blood flow and the severity of the reactions of cerebral vessels to the introduction of a stimulant and a blocker of nitric oxide synthesis were higher. Compounds VMA-13-15 and VMA-13-17 are promising for further study of their therapeutic potential in cerebrovascular accidents.

Keywords

quinazoline-4(3Н)-one, brain ischemia, neurological deficit.

Contacts

Бакулин Дмитрий Александрович – к. м. н., доцент кафедры клинической фармакологии и интенсивной терапии, Волгоградский государственный медицинский университет, e-mail: mbfdoc@gmail.com