UDK: 615.27

THE EFFECT OF DRUGS OF VARIOUS PHARMACOLOGICAL GROUPS ON THE RESPIROMETRIC FUNCTION OF MITOCHONDRIA IN CONDITIONS OF CHRONIC TRAUMATIC ENCEPHALOPATHY

K.A. Miroshnichenko, M.V. Chernikov

Пятигорский медико-фармацевтический институт – филиал ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, г. Пятигорск, кафедра фармакологии с курсом клинической фармакологии

Abstract

Chronic traumatic encephalopathy (CTE) is a severe neurodegenerative pathology that develops as a result of repeated concussions of the brain, leading to disability and death of the patient. Materials and methods. Pathology modeling was carried out by traumatic impact on the parietal region of the rat skull with a weight of 150 g from a height of 50 cm for 7 days. The studied compounds were choline alfoscerate, hopanthenic acid, aminophenylbutyric acid, citrulline malate, and sodium polydihydroxyphenylenethiosulfonate. Results. Significantly significant normalization of mitochondrial respirometric function was found in the conditions of CTE. Conclusions.After analyzing the results, we can assume the presence of a cerebroprotective effect in these drugs by restoring the respirometric function of the mitochondria of brain cells.

Keywords

chronic traumatic encephalopathy, mitochondrial dysfunction.

Contacts

Мирошниченко Кирилл Александрович – аспирант кафедры фармакологии с курсом клинической фармакологии, Пятигорский медико-фармацевтический институт – филиал ФГБОУ ВО ВолгГМУ Минздрава России, е-mail: K220436@yandex.ru