Journal of VolgSMU
Quarterly scientific-practical journal

UDK: 616.018.74-008.6:616.137.83/.86-004.6-089

ENDOTHELIAL DYSFUNCTION IN SURGERY OF AORTO-FEMORO-POPLENOUS SEGMENTS OF ATHEROSCLEROTIC GENESIS

V.A. Lazarenko, E.A. Bobrovskaya, A.A. Petrova

ФГБОУ ВО «Курский государственный медицинский университет» Министерства здравоохранения Российской Федерации, г. Курск кафедра хирург

Abstract

The features of endothelial functional activity in patients with obliterating atherosclerosis with lesions of the femoral-popliteal (n = 140) and aorto-femoral (n = 97) segments before and after reconstructive interventions were studied. Endothelial status was assessed in systemic and local blood flow. There were no differences depending on the level of lesion in the content of homocysteine and the adhesive form of endothelial dysfunction. In the case of proximal lesions observed significantly high levels in systemic and local blood flow oxidized LDL and annexin V, and PAI-1 in systemic blood, with the distal – lower t-PA in the system (of 15,8 %, p = 0,013) and local (32,6 %, p = 0,0005) the bloodstream). There was an increase in prothrombotic potential during distal arterial reconstructions in the systemic blood flow (7,7 %, p = 0,009) and revascularized segment (26,5 %, p < 0,001) and an increase in apoptosis in the operated limb (17,6 %, p = 0,03) compared to proximal reconstructions.

Keywords

arteriosclerosis obliterans, aorto-femoral bypass, femoral-popliteal bypass, endothelial dysfunction.

Contacts

Бобровская Елена Анатольевна – д. м. н., доцент, доцент кафедры хирургических болезней ФПО, Курский государственный медицинский университет, e-mail: ea-bobrovskaya@yandex.ru