UDK: 616.5-004.1:616.15-07:577.15

CLINICAL AND DIAGNOSTICAL SIGNIFICANCE OF ENZYME ACTIVITY EVALUATION OF THE PURINE METABOLISM ADENYLIC POOL IN LYMPHOCYTES AND RED BLOOD CELLS OF PATIENTS WITH SYSTEMIC SCLERODERMA

A. B. Zborovski, N. B. Abramov

НИИ клинической и экспериментальной ревматологии РАМН

Abstract

Significant decrease of adenine deaminase activity in erythrocytes and increase of adenosine deaminase and adenine deaminase activities together with decrease of AMP-deaminase activity in lymphocytes of patients with systemic scleroderma was discovered after the treatment course. Differences between all degrees of pathological process activity were demonstrated to be significant. Evaluation of activity of the enzymes under investigation promoted more precise diagnostics of the degree of process activity and the control therapy efficiency in patients with systemic scleroderma.

Keywords

adenosine deaminase, AMP deaminase, adenine deaminase, systemic scleroderma.

Contacts

Зборовский Александр Борисович, д.м.н., прфессор, заслуженный деятель науки РСФСР, академик РАМН – профессор кафедры госпитальной терапии ВолГМУ, директор ГУ НИИ клинической и экспериментальной ревматологии РАМН, complex@vistcom.ru