UDK: 615.214:616.89-008.441.13-008.6-092.4

EFFECT OF HEPTRAL ON THE COGNITIVE FUNCTIONS OF RATS AFTER CHRONIC ALCOHOL INTOXICATION

L.E. Borodkina 1, Yu.A. Smolnyakova 1, E.A. Muzyko 1, Ya.V. Tivon 2 , Ya.V. Tivon 2 , I.N. Tyurenkov 1

1 Волгоградский государственный медицинский университет, Волгоград, Россия 2 ⃰ , # Городская клиническая больница скорой помощи № 25, Волгоград, Россия

Abstract

The aim of this study was assess the effect of the heptral on the cognitive functions of female rats exposed to chronic alcohol intoxication (CAI). CAI was modeled with 6-month replacement of drinking water with a 10% solution of ethyl alcohol with sucrose (50 g/l). The "One-way step-down inhibitory (“passive”) avoidance test", "Extrapolation escape task test", "Novel object recognition test" and "Barnes maze test" were carried out at the age of 16 months. The experimental data obtained indicate that there is impairment in preservation of the memory track in female rats after CAI. Heptral neutralized cognitive impairment in animals exposed to prolonged alcohol abuse.

Keywords

chronic alcohol intoxication, cognitive functions, heptral

Contacts

Елена Андреевна Музыко, muzyko.elena@mail.ru