UDK: 615.03

RESEARCH OF THE RENOPROTECTIVE EFFECT OF A COMBINATION OF THE PEPTIDE MIMICKING THE SPATIAL STRUCTURE OF THE B ERYTHROPOIETIN CHAIN AND INFLIXIMAB IN A RENAL ISCHEMIA-REPERFUSION INJURY MODEL

A.S. Netrebenko 1, V.V. Gureev 1, M.V. Pokrovskii 1, V.I. Yakushev 1, E.V. Avdeeva 2, A.V. Gureeva 2, M.A. Zatolokina 2

Белгородский государственный национальный исследовательский университет, Белгород Россия 2 Курский государственный медицинский университет, Курск, Россия

Abstract

Purpose.The search for drugs that can prevent the development of acute renal injury (ARI) is one of the main tasks of modern pharmacology. Methods.The experiment was carried out in 50 white Wistar male laboratory rats weighing 280–320 g. The animals were injected with a peptide mimicking the spatial structure of the B erythropoietin chain (pHBSP) and infliximab. Results.The combined use of a peptide mimicking the spatial structure of the B erythropoietin chain (pHBSP) and infliximab before renal ischemia-reperfusion injury is more effective than the nephroprotective properties of the above substances when it is selectively used. Conclusion. According to the results of the study, we can talk about the prospects of the combined use of the peptide mimicking the spatial structure of the B erythropoietin chain (pHBSP) and infliximab in order to correct renal ischemia-reperfusion injury.

Keywords

pHBSP, infliximab, renal ischemia-reperfusion injury, rat, microcirculation

Contacts

Владимир Владимирович Гуреев, produmen@yandex.ru