UDK: 615.033.1

SAFETY ASSESSMENT OF KAPPA-OPIOID ANALGETICS – COMPOUNDS RU-1205

L.I. Bugaeva 2, S.A. Lebedeva 2, E.A. Kuzubova 2 , T.D. Denisova 2, Yu.V. Lifanova 1, N.V. Eliseeva 1, O.Yu. Grechko 1, A.A. Spasov 1, 2

1Волгоградский государственный медицинский университет, Волгоград, Россия 2Научный центр инновационных лекарственных средств с опытно-промышленным производством, Волгоград, Россия

Abstract

The effect of Pharmacological substance (PS) RU-1205 on organs and systems of rats was studied after 3 months of intragastric administration in doses of 5, 50, 500 mg/kg. PS RU-1205 with long-term administration did not have clinically significant effects on the indices of the integral state of animals (dynamics of body weight, consumption of water and food, general condition of animals), as well as on hematological and biochemical parameters of blood. It was shown that PS RU-1205 has a reversible mild inhibitory effect on all studied forms of behavioral activity. Pathomorphological assessment of liver and kidney micropreparations revealed a reversible adverse effect of PS RU-1205 at a dose of 500 mg/kg.

Keywords

kappa agonist, chronic toxicity, open field, biochemical studies, hematological studies

Contacts

Юлия Викторовна Лифанова, j_semenova_pharm@mail.ru