Journal of VolgSMU
Quarterly scientific-practical journal

UDK: 6012.66:612.13::611.149

AGE-RELATED ADAPTATION OF PORTAL HEMODYNAMICS IN RATS DURING 75 DAY FOLLOW-UP

Alexander A. Vinogradov , Irina V. Andreeva, Evgeniya S. Simakova

Рязанский государственный медицинский университет имени академика И.П. Павлова, Рязань, Россия

Abstract

The age-related adaptation of portal hemodynamics was studied in young rats by ultrasound methods. In the mode of color Doppler mapping, a color signal was visualized in the projection of the portal vein, and in the spectral Doppler mode, the spectrum of blood flow in the portal vein was visualized. The diameter and cross-section of the portal vein, linear and volumetric blood flow rates were determined. The study was performed at the beginning and after 60- and 75-day follow-up. It was found that the portal hemodynamics parameters were influenced by a change in the diameter of the portal vein. With an increase in the diameter of the portal vein, the linear velocity of blood flow in the portal vein decreased, but the volumetric velocity of blood flow in the portal vein increased. Conclusions. The mechanisms of age-related adaptation of portal hemodynamics include compensa-tion for a decrease in the linear velocity of blood flow by increasing the volumetric velocity of blood flow in the portal vein.

Keywords

rat, age adaptation, portal hemodynamics

Contacts

alexanvin@yandex.ru