UDK: 615.07

PHARMACOLOGICAL ANALYSIS OF THE MECHANISMS OF ACTION OF A QUINOXALINE DERIVATIVE WITH ANXIOLYTIC PROPERTIES

M.O. Skripka 1,2, D.V. Maltsev 1,2, A.A. Spasov 1,2,3, M.A. Perfiliev 1,3

1Волгоградский государственный медицинский университет, Волгоград, Россия 2Волгоградский медицинский научный центр, Волгоград, Россия 3 Научный центр инновационных лекарственных средств, Волгоград, Россия

Abstract

The interactions of compound ZDM-81 with some CNS neurotransmitter systems were studied using in vivo methods to evaluate the interaction of the compound with dopaminergic (catalepsy, induced with haloperidol), adrenergic (clonidine hypothermia), GABAergic (test of interaction with flumazenil) and serotonergic (5-hydroxytryptophan hyperkinesis) systems. It was shown that the ZDM-81 compound is able to prolong and potentiate the effects of 5-hydroxytryptophan, reduces catalepsy caused by haloperidol, does not affect the hypothermic effect of clonidine, and the effect of the ZDM-81 compound is blocked by flumazenil. Thus, for the studied substance, a serotonergic, GABAergic, and weak dopaminergic pathway for the realization of the action was shown, which requires further research.

Keywords

pharmacological analysis, flumazenil, 5-GTP, anxiolytic, haloperidol, quinoxalines

Contacts

Мария Олеговна Скрипка, rete.mirabile.renis@gmail.com