UDK: 577.1:618.14

HUMAN TELOMERASE REVERSE TRANSCRIPTASE (HTERT) AND ASSOCIATED DISEASES OF UTERUS

L. V. Adamyan, H. Z. Gusaeva, I. A. Marchenko

Научный центр акушерства, гинекологии и перинаталогии им. В. И. Кулакова, НИИ Молекулярной Медицины, НИЦ ММА им. И. М. Сеченова, Москва

Abstract

hTERT is a rate-limiting determinant of telomerase activity. We have studied the expression of hTERT gene in samples of myoma, of adenomyosis, of simple hyperplasia, of atypical hyperplasia. hTERT gene expression was evaluated by reverse transcriptase polymerase chain reaction (RT-PCR) with microglobulin as an indirect marker of tissues integrity. None of theinvestigated samples had any hTERT gene expression. ASample of endometrial cancer was positive for hTERT gene expression.

Keywords

telomerase, associated diseases of uterus

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