UDK: 612.17:615.015].001.6

EFFECT OF CARDIOSELECTIVITY AND INTRINSIC SYMPATHOMIMETIC ACTIVITY OF BETA-ADRENORECEPTOR BLOCKERS ON HEART RATE VARIABILITY IN WAKING AND NARCOTIZED RATS

E. V. Salnikov, M. M. Fateev, V. N. Fedorov, A. V. Sidorov

Ярославская государственная медицинская академия

Abstract

In narcotized and waking immobilized rats -adrenoreceptor blockers led to an increase in the total heart rate variability, adaptation capability; they enhanced parasympathetic activity and decreased the sympathetic one. Increase in LF power in waking immobilized rats in the presence of -adrenoreceptor blockers requires a comprehensive study to define more precisely the physiological role of this parameter. Among three -adrenoreceptor blockers pindolol demonstrated the least activity compared to preparations without intrinsic sympathomimetic activity such as propranolol (most pronounced effect in narcotized rats) and bisoprolol (more effective in waking immobilized rats).

Keywords

-adrenoreceptor, intrinsic sympathomimetic activity, heart rate variability

Contacts

Сальников Евгений Валентинович — к. м. н., доцент кафедры биологии Ярославской государственной медицинской академии (ЯГМА). 150000, Ярославль, ул. Революционная, 5, Ярославская государственная медицинская академия, кафедра биологии. Тел.: (4852)73-96-23.