UDK: 616.72-002.775:577.156.6

CLINICOPATHOGENETIC IMPORTANCE OF ANALYSIS OF PURINE METABOLISM ENZYME ACTIVITY IN LYMPHOCYTE LYSATES AND ERYTHROCYTES OF PATIENTS WITH OSTEOARTROSIS

Yu. I. Gerusov, I. A. Zborovskaya, V. F. Martemjanov, S. A. Bedina, E. E. Mozgovaya

НИИ Клинической и экспериментальной ревматологии РАМН

Abstract

Activities of adenosine deaminase (ADA), adenosine monophosphate deaminase (AMPHDA) and adenin deaminase (AD) were determined depending on clinical features of the disease in lyzates of lymphocytes and erythrocytes in blood of 52 patients with ostheoarthrosis. The results of the investigation demonstrated that the greatest changes in enzymatic activity were observed in patients with synovitis and a high degree of functional insufficiency of the joints. A severe course of the disease was accompained by a considerable reduction of the activity of ADA in lymphocytes and a high activity of ADA, AMPHDA and AD in erythrocytes. Investigation of enzymatic activity promoted the control of objectivity and effectiveness of treatment.

Keywords

ostheoarthrosis, adenosine deaminase, adenosine monophosphate deaminase, adenin deaminase

Contacts

Зборовская Ирина Александровна — д. м. н., профессор, зав. кафедрой госпитальной терапии, военно-полевой терапии с курсом клинической ревматологии ФУВ ВолГМУ, E-mail: rheuma@vlink.ru