UDK: 615.015+616.001.8

EFFECT OF SOME NEUROTROPIC SUBSTANCES ON OXYGEN CONSUMPTION IN MITOCHONDRIA OF RAT BRAIN

V. V. Yasnetsov

ОАО «Всероссийский научный центр по безопасности биологически активных веществ», Московская область, г. Старая Купавна

Abstract

It was estimated by polarographic measurement of oxygen consumption in rat brain mitochondria that a new substance IBCP-2 (in about a half of all cases), mexidol and amtizol succinate can nearly equally increase oxygen consumption. Other new substances IBCP-1 and IBCP-3 as well as amtizol and emoxipin, have no such ability. Unlike preparations including succinate (mexidol and amtizol succinate), IBCP-2 stimulates mitochondrial respiration by way of complex I.

Keywords

mitochondrial respiration, polarographic measurement, neurotropic substances

Contacts

Яснецов Виктор Владимирович — к. м. н., научный сотрудник ОАО «Всероссийский научный центр по безопасности биологически активных веществ», e-mail: vicyas@yandex.ru