UDK: 615.015: 615.262.1: 616.72-002-085.262.1

EARLY RHEUMATOID ARTHRITIS: CONCEPT OF EARLY DIAGNOSTICS AND TREATMENT

A. R. Babaeva, E. V. Tcherevkova, K. S. Solodenkova

Кафедра факультетской терапии ВолГМУ

Abstract

This review provides novel information on pathogenesis, clinical сharacteris-tics, diagnostic and therapeutic approaches to early rheumatoid arthritis. TA possibility of affecting the natural course of this disease using early, aggressive diseasemodifying antirheumatic therapy is discussed. Rapid and sustained disease control with biologics was shown in recent placebo-controlled studies. The novel original preparations containing ultra-low doses of antibo-dies against tumor necrosis factor-a (TNF-a) and interferon-g (INF-g) were approved for rheumatoid arthritis treatment. Our previous investigations have confirmed good efficacy and safety of ultra-low anti-TNF-a preparation (artro-foon) and its combination with ultra-low anti-INF-g (anaferon) in long-term rheumatoid arthritis therapy. The possibilityof preventing disease progression prevention using these drugs in early rheumatoid arthritis should be assessed.

Keywords

early rheumatoid arthritis, therapy, ultra-low doses, anti-TNF-, anti-INF-, artrofoon, anaferon

Contacts

Бабаева Аида Руфатовна — д. м. н., профессор, зав. кафедрой факультетской терапии Волгоградского государственного медицинского университета, e-mail: babaeva_ar@volgmed.ru