UDK: 616.33/34-008.5-07

PATHOGENESIS OF FUNCTIONAL GASTROINTESTINAL DISORDERS: CURRENT STATE OF THE PROBLEM

Кафедра факультетской терапии ВолГМУ

Abstract

The overview of literature summarises the modern concept of pathogenesis of functional gastrointestinal disorders (FGID). It expounds the role of the proved pathogenetic factors and presents the contribution of separate hormonal systems including the diffuse neuroendocrine system (DNES). Our own data on the thyroid and psychological status and particular features of extraorgan manifestations in FGID patients are presented. The authors offer a new concept of FGID development mechanisms including central (involving brain structures, change of separate mediator and/or hormones production), local (neuromuscular organ disregulation) and peripheral (sensitivity change of the target organ receptive apparatus) links.

Keywords

functional dyspepsia, irritable bowel syndrome, serotonin, melatonin, free triiodothyronine (fТ3), free tetraiodothyronine (fТ4)

Contacts

Бабаева Аида Руфатовна — доктор медицинских наук, профессор, зав. кафедрой факультетской терапии Волгоградского государственного медицинского университета, e-mail: babaeva_ar@volgmed.ru