UDK: 615.281.8:612.017.1

IMMUNOMODULATORY PROPERTIES OF NEW ADENINE DERIVATIVES

P. P. Nesmiyanov

Кафедра клинической фармакологии и интенсивной терапии ВолГМУ

Abstract

Five compounds (VMA-03-01, VMA-01-21, VMA-99-56, VMA-99-82, VMA-00-29) were evaluated for their in vitro and in vivo immune-modulating effects. VMA-03-01, VMA-01-21, VMA-99-56 have been shown to increase phagocytosis and microbicidal activity in human neutrophils, thus affecting innate immunity. All compounds affect early and late stages of T cell activation, which is shown by measurement of CD69+ and CD25+ T cells. In the rat model, compounds VMA-03-01 and VMA-01-21 inhibit specific antibody production.

Keywords

immune modulation, immunity, phagocytosis, adenine derivatives

Contacts

Несмиянов Павел Павлович — ассистент кафедры иммунологии и аллергологии, аспирант кафедры клинической фармакологии и интенсивной терапии Волгоградского годсударственного медицинского университета, e-mail: pecatum@yandex.ru