UDK: 577.15: 591.436:615.33

ENZYMATIC ACTIVITY OF LIVER IN EXPERIMENTAL ANIMALS UPON INTRODUCTION OF LIPOSOMAL ZEFAZOLIN

S. N. Tikhonov, K. A. Rotov, V. V. Alekseev, E. A. Snatenkov, N. P. Khrapova

Волгоградский научно-исследовательский противочумный институт

Abstract

The paper presents data on the production of liposomal preparation of cefazolin, with evaluation of its physical and chemical properties. A comparative study of the influence of cefazolin in its free and liposomal forms on the activity of liver enzymes in white mice determined that immobilization of antibiotics in nanoliposomes decreased their inhibitory action on protease, alkaline phosphatase and phosphorylase

Keywords

аntibiotics, cefazolin, nanoliposomes, liver enzymes

Contacts

Алексеев Владимир Валерьевич — доктор меди- цинских наук, профессор, директор Волгоградского научно-исследовательского противочумного института Роспотребнадзора, e-mail: vari2@sprint-v.com.ru