Journal of VolgSMU
Quarterly scientific-practical journal

UDK: 616-002 — 008.953-092

OXYGEN-REALTED BIOCIDITY OF NEUTROPHILS IN RATS WITH PARODONTAL INFLAMMATION IN HYPOTHYROIDISM

L. V. Vokhmintseva, S. S. Rymar

Новосибирский государственный медицинский университет

Abstract

To study the effect of experimental hypothyroidism on oxygen-related neutrophils biocidity in a rat model of acute gingival trauma we investigated the spontaneous and stimulated nitroblue tetrazolium test. Hypothyroid state in rat was induced by administration of 25 mg/kg mercazolyl for 21 days. Inflammation in rats with acute gingival trauma and hypothyroidism leads to a reduction in spontaneous and stimulated nitroblue tetrazolium test, diminished levels of malondialdehyde and glutathione in gingival tissue, a decrease in serum malondialdehyde level and in hemolysate glutathione level.

Keywords

parodontal inflammation, hypothyroidism, nitroblue tetrazolium test

Contacts

Вохминцева Лариса Вениаминовна — к.м.н., доцент кафедры биологической химии Новосибирского государственного медицинского университета, e-mail: vokhmintseva@yandex.ru