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Evaluation of toxicity of antigens of burkholderies in different types of cells

Волгоградский научно-исследовательский противочумный институт, кафедра биологии ВолГМУ

Abstract

The results of exaluation of toxicity of water-salt extracts of pathogenic burkholderies (B.pseudomallei, B.mallei) and non-pathogenic (B.thailandensis) variants in four types of cells: mice fibroblasts L-929, cells of Chinese hamster ovarial tumor, CHO KI-1, mice BALB/c macrophages and infusoria Paramecium caudatum were presented. It was shown that as for sensitivity method of defifnition of toxicity in infusoria is close to testing in cells CHO K-1 and L-929. Defining toxicity toses causing death of infusoria but not damaging them may be simple and accessible.

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Contacts

Волгоградский научно-исследовательский противочумный институт, vari@sprint-v.com.ru