UDK: 616.33-002.153-022-616.9.001.6

Experimental model of Helicobacter-like of gastic mucosal injury

Spasov A.A., Chernikov M.V., Speranskaya A.S., Zaichenko S.I.

Кафедра фармакологии, кафедра судебной медицины ВолГМУ, ВНЦ РАМН, лаборатория экспериментальной фармакологии

Abstract

The present study was designed to examine the role of ammonia-monochloramine system in gastic mucosal injury. Mucosal application of ammonia in sub erosive concentration (100 mM) leads to insignificant lesions in unanesthetized rat stomach. Mucosal exposure to ammonia (100 mM) plus acute ischemia by bleeding from the carotid artery followed monochloramine synthesis caused severe hemorrhagic gastric lesions. These results suggest that monochloramine damages the gastric mucosa at much lower concentration than ammonia and this testing procedure may be used as a model of Helicobacter pylori-associated injury of gastric mucous.

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Contacts

Черников Максим Валентинович – д.м.н., доцент, зав.кафедрой биологии, volgabiolog@mail.ru