Journal of VolgSMU
Quarterly scientific-practical journal

UDK: 616.12-008.331.1

ENDOTHELIAL FUNCTION AND CARDIOVASCULAR REMODELING IN ARTERIAL HYPERTENSION

E. A. Grigoricheva, L. V. Sigidiova

Челябинская государственная медицинская академия

Abstract

Ultrasound study of the heart and vessels was performed in 105 patients with arterial hypertension and 20 apparently healthy individuals. Normal endothelial function was noted in 26 patients (24 %), signs of endothelial dysfunction — in 79 patients (76 %). A disrupted ability of the brachial artery to relax corresponded to decreased blood flow in the medial cerebral artery and parenchymatous renal blood flow (with an increased creatinin level). Patients with left ventricular hypertrophy revealed an endothelial reaction in the form of increased endothelial shift (increased velocity without an increase in vascular diameter), slowed-down time of vascular diameter restoration and decreased hemostatic ability of the vascular wall.

Keywords

arterial hypertension, endothelial function, heart remodeling

Contacts

Григоричева Елена Александровна — д. м. н., профессор кафедры поликлинической терапии Челябинской государственной медицинской академии, e-mail: Lenaqriq@rambler.ru