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THE ROLE OF LEPTIN AND NEUROPEPTIDE Y IN PATHOGENESIS OF REPRODUCTIVE DYSFUNCTIONS IN ADOLESCENT GIRLS WITH ANOREXIA NERVOSA

V. O. Andreeva

Ростовский научно-исследовательский институт акушерства и педиатрии

Abstract

Serum leptin and neuropeptide Y levels have been determined in 2 studied groups of patients and in the control group. A decreased leptin level was found at the anorectic stage, and hyperproduction of leptin was found at the stage of reduction of anorexia nervosa. It was also determined that leptin level is not depend on BMI. Hypoleptinemia of anorectic stage was accompanied by a decreased neuropeptide Y level, which indicates formation of resistance to the low leptin level that may be caused by a disorder of leptin transport through the hematoencephalic barrier and by hypoinsulinemia.

Keywords

leptin, neuropeptide Y, anorexia nervosa, reproductive dysfunction, adolescent girls

Contacts

Андреева Вера Олеговна — д. м. н., ведущий научный сотрудник акушерско-гинекологического отдела ФГУ «Ростовский научно-исследовательский институт акушерства и педиатрии Росмедтехнологий», e-mail vandreyeva@mail.ru.