UDK: 616.12-008.441.33-085.31

THE REINFORCEMENT OF RENIN-ANGEOTENSIN-ALDOSTERON SYSTEM BLOCKAGE: COMPARISON OF THE RESULTS OF THE MONOTHERAPY BY CARDOSTEN AND THE COMBINATION OF CARDOSTEN AND ENALAPRIL AMONG THE PATIENTS WITH ARTERIAL HYPERTENSION IN COMBINATION WITH METABOLIC SYNDROM

E. V. Frolova, A. A. Avdienko

Кафедра клинической фармакологии и интенсивной терапии ВолГМУ

Abstract

We studied the possibility of extra blockage of renin-angeotensin-aldosteron system as a result of combined therapy by ultra small doses of antibodies to C-end fragment of AT-1 receptor of angiotensin II cardosten and angiotensin-converting enzyme inhibitor among patients with the first degree arterial hypertension in combination with metabolic syndrome. The angiotensin-converting enzyme inhibitor enalapril supplement in dose of 10 mg two times a day to the monotherapy by cardosten speeds up and strengthens the hypotensive effect, it favorably influences on the data of lipid and carbohydrate metabolism during first three months of treatment. Further the phenomenon of “recession effect” develops and the results of treatment aren’t different from the monotherapy by cardosten.

Keywords

arterial hypertension, metabolic syndrome, renin-angeotensin-aldosteron system, cardosten, enalapril

Contacts

Фролова Екатерина Викторовна — заместитель главного врача по медицинской части клиники семейной медицины ВолГМУ, e-mail: e.v.frolova@mail.ru.