UDK: 618.19-006.6]-035.2-092:612.017.1]-008.6(045)

Insufficiency of nonspecific resistance mechanisms and specific host-defense mechanisms as breast cancer risk factor

V. N. Plohov, V. Yu. Barsukov, N. P. Chesnokova, T. D. Selezneva

Кафедра онкологии с курсом онкологии ФУВ ВолГМУ, Саратовский ГМУ им. В. И. Разумовского*

Abstract

Development of immunodeficiency prior to neoplasia is a factor of insufficient elimination of spontaneously formed malignant cells and, correspondingly, the factor leading to the subsequent carcinogenesis stage, promotion. Methods of non-adjuvant and adjuvant polychemotherapy used nowadays aggravate insufficiency of nonspecific resistance mechanisms and, thereby, alongside with eradicating tumor cells, these methods are a factor of metastasis of tumor cells (they pass to mitosis phase) while prior to polychemotherapy these cells were dormant.

Keywords

humoral immunity, breast cancer

Contacts

Плохов Владимир Николаевич — д. м. н., профессор кафедры онкологии с курсом онкологии ГОУ ВПО «Волгоградский государственный медицинский университет Росздрава», директор НУЗ Отделенческая клиническая больница на станции Волгоград-1 ОАО «РЖД», e-mail: ploh