UDK: 616.982.27-039-092.576.8

Immunogenic and protective properties of cultural filrates from meliodosis causative agents

Zhukova S.I., Pyven N.N., Avrorova I.V., Proshina O.B., Plekhanova N.G., Drefs N.M., Zasyagrina A.V.

Волгоградский научно-исследовательский противочумный институт

Abstract

Cultural filtrates were obtained during cultivation of typical strains B.pseudomallei of full-valued antigenic structure 100 and 111, and its atypical variants without antigen 8 and some proteins of external membrane. Study of protective properties of CF revealed a certain dependence between protective action of CF and levels of protease and haemolysins production. These strains were more active in stimulating cell immunity and macrophage systems.

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Волгоградский научно-исследовательский противочумный институт, vari@sprint-v.com.ru