Journal of VolgSMU
Quarterly scientific-practical journal

UDK: 616-005.4:547.466.3:615272.4

Effect of gaba structural analog on lpo and on activity of antioxidant enzymes in ischemic myocardial lesion

V. N. Perfilova, I. N. Tjurenkov, O. J. Grechko, Y. V. Lamtyugin

НИИ фармакологии ВолГМУ, кафедра фармакологии и биофармации ФУВ ВолГМУ

Abstract

The influence of new GABA structural analog on LPO processes and antioxidant system activity in myocardial ischemia lesion has been studied. It is shown that in the group of animals with occlusion of left coronary artery descending branch, which had received RGPU-147 compound intravenously in dose 50 mg/kg, the content of DK, KA and MDA in cytoplasm of the affected cardiac hystiocytes was increased by 116,6; 40 and 40,8 % correspondingly in comparison with tissues of intact myocardial zones, whereas analogous indices in control group increased by 341.6; 118; 61,9 %. SOD and GPO enzymes activity as well as the concentration of reduced glutathione in cytoplasm of ischemic myocardial area of animals, which had received RGPU -147 compound, were decreased by 18.1; 11.5 and 32.5 % correspondingly, relative to recorded indices of unaffected areas, in control group of animals — by 35,2; 29,7; 52,3 % correspondingly

Keywords

GABA structural analog, myocardium ischemia lesion, LPO products, antioxidant action

Contacts

Перфилова Валентина Николаевна — к. б. н., старший научный сотрудник кафедры фармакологии и биофармации ФУВ, e-mail: vnperfilova@mail.ru