UDK: 616-006.448

An attempt to mobilize autologous peripheral stem hemopoietic cd34+ cells in multiple myeloma

K. D. Kaplanov, L. S. Tregubova, T. Iu. Klitochenko, I. V. Matveeva, K. S. Momotiuk, A. L. Shipaeva

Волгоградский областной клинический онкологический диспансер № 1

Abstract

The effectiveness of the CD34-positive cell harvesting in multiple myeloma patients treated with four courses of PAD (bortezomib, adriablastin, dexametasone) was evaluated. As soon as treatment was finished patients were reevaluated. Three patients who had achieved complete or good partial remission received high-doses of cyclophosfamide. Then their bone marrow was stimulated with G-CSF and CD34-positive cells were collected. In all three cases the number of CD34-positive cells harvested was enough for transplantation and bone marrow repopulation. CD34-positive cells counting and cryopreservation were performed in National Centre for Hematology [Moscow]. The results of this work are crucial for introduction of modern programs of intensive treatment of hematooncological patients.

Keywords

multiple myeloma, high-dose therapy, hemopoietic stem cells, autologous transplantation, bortesomib (Wellcaid)

Contacts

Капланов Камиль Даниялович — к. м. н., зав. отделением гематологии ГУЗ Волгоградский областной клинический онкологический диспансер №1, e-mail: kamilos@mail.ru