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Value of pharmacokinetic typing for cyp2c9 activity to enhance pharmacotherapy of type ii diabetes in indigenous people of the republic of kalmykia

V. I. Petrov, N. V. Rogova, D. O. Mikhailova, Y. M. Ledyaev, D. M. Serdukova, O. M. Tyaginova

Кафедра клинической фармакологии ВолГМУ

Abstract

With a view to finding a way to enhance pharmacotherapy for type II diabetic patients in indigenous people of the Republic of Kalmykia there was first carried out a pharmacokinetic typing for CYP2C9 activity with the help of high performance liquid chromatography. The study revealed a high incidence of the phenotypes that characterize reduced CYP2C9 activity in this ethnic group, which allows us to recommend evaluation of the CYP2C9 activity so as to enhance pharmacotherapy by using sulfonylurea derivatives and reduce the risks of developing undesirable drug reactions.

Keywords

diabetes type II, high performance liquid chromatography, pharmacokinetic typing, CYP2C9 activity, enhancement of pharmacotherapy

Contacts

Петров Владимир Иванович — Заслуженный деятель науки РФ, Заслуженный врач РФ, Академик РАМН, д. м. н., профессор, зав. кафедрой клинической фармакологии и интенсивной терапии с курсами клинической фармакологии ФУВ, клинической аллергологии ФУВ, восстанови