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Fixed combination of enalapril and hydrochlorothiazide as a drug for initial treatment of arterial hypertension

Kaplanov T.D., Ivanenko V.V., Ilyukhin O.V., Kalganova E.L., Lopatin Yu.M.

Кафедра кардиологии с функциональной диагностикой ФУВ ВолГМУ, Волгоградский областной кардиологический центр

Abstract

The article is focused on the results of a six-month open non-comparative research of the fixed combination of enalapril and hydrochlorothiazide (Enap-Н) which were given for initial treatment of arterial hypertension (AH). Antihypertensive efficacy and Enap-Н ability to influence cardiovascular remodeling were studied in 25 high risk AH patients who didn’t receive drug therapy before. Research has shown high antihypertensive activity of the drug and its positive effect on the heart and vessels remodeling. However, Enap-Н therapy caused significant increase of the uric acid level and this condition demands controlling blood biochemical parameters in the course of drug therapy.

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Contacts

Илюхин Олег Владимирович – к.м.н., ассистент кардиологии ФУВ с курсами функциональной и лучевой диагностики, кардиохирургии и клинической лабораторной диагностики ФУВ ВолГМУ, sim@sprint-v.com.ru