UDK: 615.07:543.062:577.175.5

DEVELOPMENT OF A METHOD FOR QUANTIFICATION BIOGENE AMINES AND THEIR METABOLITES IN RATS BRAIN STRUCTURES

A. F. Rjabuha, E. A. Suchkov, A. V. Mekenja, E. V. Djakova, D. G. Kovalev, L. A. Smirnova

Лаборатория фармакокинетики, лаборатория психофармакологии НИИ фармакологии ВолГМУ

Abstract

Analysis of the low levels of biogenic amines and metabolites in tissue and biological fluids has necessitated the use of highly sensitive analytical techniques. W e describe a sensitive, simple and selective high-perfor mance liquidchromatographic method for measuring noradrenaline, dopamine, serotonin, 3,4-dihydroxyphenyl acetic acid, 5-hydroxyindolacetic acid in brain tissue of rats.

Keywords

biogenic amines, quantification method, fluorescent detector

Contacts

Ковалев Дмитрий Геннадьевич — к. м. н., зав.лабораторией психофармакологии ВолГМУ, e-mail: kovalev_dmi@mail.ru