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STUDY OF ENDOTHELIOPROTECTIVE EFFECTS OF DIFFERENT DRUG GROUPS ON MODELS OF L-NAME-INDUCED DEFICIENCY OF NITROGEN OXIDE

M. V. Pokrovskiy, V. I. Kochkarov, T. G. Pokrovskaia, E. B. Artiushkova, E. N. Pashin, L. M. Danilenko, M. V. Korokin, A. S. Belous, V. A. Malyhin

Курский государственный медицинский университет

Abstract

The modelling of deficiency of oxide nitrogen introduction L-NAME to rats led to development of arterial hypertension, increase in the factor of endothelial dysfunction, decrease in the maintenance of nitrates/nitrites levels, hypertrophy of cardiomyocytes. Introduction of donors NO, activators of No-sintase, antioxidants, antihypertensive drugs has revealed comparable endotelioprotective effects.

Keywords

oxide nitrogen, L-NAME, endothelial dysfunction

Contacts

Покровский Михаил Владимирович — д. м. н., профессор, зав. кафедрой фармакологии Курского государственного медицинского университета, e-mail: mvpokrovskiy@pharmstd.ru