UDK: 616.72-002.77:616.441-08-07-097

CLINICAL AND DIAGNOSTIC VALUE OF EVALUATION OF ANTIBODIES TO THYROID HORMONES IN PATIENTS WITH RHEUMATOID ARTHRITIS

O. V. Paramonova, I. P. Gontar, A. V. Alexandrov, A. I. Romanov

Кафедра госпитальной терапии ВолГМУ, Научно-исследовательский институт клинической и экспериментальной ревматологии РАМН, Волгоград, Центр реабилитации Управления делами Президента РФ, Москва

Abstract

A technique of immunoenzyme evaluation of antibodies (AB) to thyroid hormones (conjugated T4 and conjugated T3) on the base of immobilized magnetic sorbents, which may be used in clinical laboratories, was elaborated for the first time. AB to conjugated T4 and conjugated T3 was revealed in sera of rheumatoid arthritis (RA) patients, their concentration correlated with the pathologic process activity. Level of AB to T4 and T3 differed significantly as compared with healthy persons. Evaluation of AB to thyroid hormones may be used as a complementary test in complex diagnosis in order to characterize the activity of pathologic process and clinical forms of RA.

Keywords

rheumatoid arthritis, antibodies, thyroid hormones, immobilized magnetosorbents

Contacts

Парамонова Ольга Владиславовна — ассистент кафедры госпитальной терапии ВолГМУ, e-mail: Venera243@hotmail.com