UDK: 611-018.74

EFFECT OF SIMVASTATIN ON ENDOTHELIUM-DEPENDENT VASODILATATION OF CEREBRAL VESSELS IN ANIMALS WITH STREPTOZOTOCIN-INDUCED DIABETES MELLITUS

I. N. Tyurenkov, A. V. Voronkov

Кафедра фармакологии и биофармации ФУВ ВолГМУ

Abstract

It was revealed that administration of simvastatin prevents disorders in the NO-synthase system in cerebral vessels of animals with experimental diabetes. We can assume that endothelium-protective effect of simvastatin is associated with stabilization of NO-synthase system, which is manifested by an improvement of vasodilatating endothe lial function and a decrease in the resistance and stiffness of the blood vessels in rats with hormonal disorders.

Keywords

endothelium dysfunction, brain, atherosclerosis, simvastatin, diabetes mellitus

Contacts

Воронков Андрей Владиславович — к. м. н., научный сотрудник НИИ фармакологии ВолГМУ, e-mail: prohor.77@mail.ru