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ROLE OF SYSTEMIC INFLAMMATORY REACTION AND ENDOTHELIAL DYSFUNCTION IN THE PATHOGENESIS OF CHOLEPERITONITIS

V. I. Sergienko, E. A. Petrosyan, A. A. Botashev, O. A. Tereshenko, U. V. Pomeshik

Кубанский государственный медицинский университет

Abstract

Experimental studies on animals with 24-hour choleperitonitis have established a doubling of leucocytes concentration and a decrease in cytochemical profile. At the same time animals had hypercytokinemia. Growth of desquamated indotheliocytes, endothelin-1 and the von Willebrand factor, NO in plasma and in the suspension of cultured leucocytes was revealed. The detected deviations of the studied markers of systemic inflammatory reaction and endothelial dysfunction can be considered as a new direction in improving the diagnosis of choleperitonitis.

Keywords

choleperitonitis, system inflammatory reaction, endothelial dysfunction.

Contacts

Петросян Эдуард Арутюнович — д. м. н., профессор, зав. кафедрой оперативной хирургии и топографической анатомии Кубанского государственного медицинского университета, e-mail: superego_ksmu@mail.ru