UDK: УДК 615.015.8

THE EFFECT OF THE DURATION OF CEFTRIAXONE ON THE CHANGES AND RESISTANCE OF THE BIOCENOSIS MICROFLORA IN RATS

P. V. Popov, B. J. Syropyatov, T. F. Odegova

Пермская государственная фармацевтическая академия

Abstract

One of the objectives of preventive antibiotic administration is to prevent the development of microbial resistance to chemotherapy, but its impact on biocenosis is unclear. We have shown distinct pathogenesis of resistant microflora in rats from bacterial monocultures. On the third day of the experimental chemotherapy, in biocenosis there begins a replacement of normal microflora by the resistant types and development of dysbiosis.

Keywords

antibiotic resistance, biocenosis, dysbiosis.

Contacts

Попов Павел Вениаминович, к. м. н., e-mail: popov.pv@list.ru