UDK: 616.24-002.191-053.2

FEATURES OF CYTOKINE-MEDIATED INFLAMMATION IN CHILDREN WITH CYSTIC FIBROSIS AND CHRONIC COLONIZATION OF BRONCHIAL TREE BY PSEUDOMONAS AERUGINOSA

D. F. Sergienko, H. M. Galimzianov, O. A. Bashkina

Астраханская государственная медицинская академия

Abstract

Levels of pro- and antiinflammatory cytokines in children with cystic fibrosis (CF) in chronic Pseudomonas aeruginosa infection depending on the severity of the disease were studied. An increase in production of pro- and antiinflammatory cytokines with an increase in severity of CF in blood serum and in sputum of patients was demonstrated. With increasing severity of the disease a decrease in cellular immune response and humoral activation was noted. High levels of IL-1, IL-6 in habitats may indirectly indicate the presence of bronchiectasis, which requires further investigation and, if necessary, correction of treatment.

Keywords

cystic fibrosis, children, cytokines.

Contacts

Сергиенко Диана Фекретовна — к. м. н., доцент кафедры факультетской педиатрии Астраханской государственной медицинской академии, e-mail: gazken@rambler.ru