UDK: 616.98.-097-022:616-002.5-091

PATHOLOGICAL CHANGES IN THE LUNGS DURING TUBERCULOSIS AT DIFFERENT STAGES OF HIV INFECTION

L. S. Byhalov, A. V. Smirnov

Волгоградский государственный медицинский университет, кафедра патологической анатомии, Волгоградский научный центр

Abstract

We revealed pathological changes in the lungs of patients who died from tuberculosis and HIV infection considering the immunological stage of the process. The structural changes were multidirectional and with CD 4+ > 200 cells/mcl (mediana is 356,2 cells/mcl) they were more similar to the pathomorphology of pulmonary tuberculosis without HIV-infection with limited foci of inflammation. As the secondary immunodeficiency progressed the number of CD 4 + ranged from 200 to 100 cells/mcl (mediana is 148,4 cells/mcl), clinical and morphological forms of pulmonary tuberculosis with destructive component prevailed and there was a tendency to generalization and inflammatory changes with exudative component. At the terminal stage CD 4+ lymphocyte count was less than100 cells/mcl (mediana is 49,4 cells/mcl), generalized forms of 2-sides milliary tuberculosis as well as alterative reactions in lung parenchyma and massive vasculitis in the microvasculature prevailed.

Keywords

pathomorfology of lungs, HIV-infection, tuberculosis, TB/HIV co-infection.

Contacts

Быхалов Леонид Сергеевич — к. м. н., докторант кафедры патологической анатомии, Волгоградский государственный медицинский университет, e-mail: leonby-vgd@yandex.ru