UDK: 611.127:611.018: 611.013:576.311.347.
N. S. Petruk, M. V. Ivanchenko, I. V. Tverdokhleb
Днепропетровская медицинская академия, Украина
The aim of this study was to determine the relationship between mitochondrial reactions and the distribution of gap junctions in contractile cardiomyocytes in postnatal ontogenesis experimentally induced by chronic intrauterine hypoxia. Electronmicroscopic analysis of rats’ ventricular myocardium showed that more than 40 % of the length of gap junctions conjugated with local mitochondrial clusters. Subsarcolemmal mitochondria were closely linked with gap junctions forming gap junctionmitochondria complexes. The interaction of gap junctions and mitochondria is conditioned by their morphological and functional features and their spatial relationship both in a mature myocardium and in the developing heart.
rat myocardium, cardiogenesis, gap junctions, mitochondria, intrauterine hypoxia.
Твердохлеб Игорь Владимирович — д. м. н., профессор, заведующий кафедрой гистологии, Днепропетровская медицинская академия, г. Днепропетровск, Украина, e-mail: ivt@dsma.dp.ua