UDK: 577.112+616.36-006-092.4

DYNAMIC CHANGES IN VIMETIN AND SMOOTH MUSCLE ACTIN RATIO IN EXPERIMENTAL CHEMICALLY INDUCED LIVER FIBROSIS

Y. I. Velikorodnaya, A. Y. Pocheptsov

Научно-исследовательский институт гигиены, токсикологии и профпатологии, Волгоград

Abstract

We demonstrated that the number of cells expressing vimentin and smooth muscle actin cells in the liver tissue was rapidly increasing in the first 4 weeks. After 8 weeks of progressing fibrosis the number of vimentin positive cells was stabilized and the number of actin positive cells continued to grow.

Keywords

liver fibrosis, extracellular matrix, immunohistochemistry, vimentin, smooth muscle actin.

Contacts

Почепцов Александр Яковлевич — заведующий лабораторией патоморфологии, ФГУП Научно-исследовательский институт гигиены, токсикологии и профпатологии ФМБА России, e-mail: pochepcov@rihtop.ru