UDK: 616-005.4

THE STRUCTURAL FEATURES OF THE HIPPOCAMPUS OF RATS WITH THE EXPRESSION OF HEAT SHOCK PROTEINS IN THE MODELING HYPERTENSIVE ENCEPHALOPATHY

A. V. Smirnov1, 2, M. V. Schmidt1, 2, D. S. Mednikov1, M. R. Ekova1, I. N. Tyurenkov1, D. V. Kurkin1, E. V. Volotova1

1Волгоградский государственный медицинский университет, кафедра патологической анатомии, кафедра фармакологии и биофармации ФУВ, 2Волгоградский медицинский научный центр, лаборатория морфологии, иммуногистохимии и канцерогенеза

Abstract

Adult rats were subjected to 28-day gravitational effects in the cranial-vector for 5 minutes twice a day with an interval of 12 hours. Detected signs of circulatory disorders: stasis, congestion, swelling, pyknotic deformation and perikarionic hyperchromia of cytoplasm. A significant reduction of the specific density of neurons, a significant increase in the relative amount of damaged neurons, significant increase in HSP 70 expression in cells of the pyramidal layer of the CA1, CA2, CA3 and CA4 zones of hippocampus, and there was a significant increase in the expression of HSP 90 in the CA1 zone, and tendency to increase HSP expression 90 in CA4 zone, indicating the activation of the adaptive neuroprotective mechanisms in the modeling hypertensive encephalopathy.

Keywords

hippocampus, hypertensive encephalopathy, heat shock proteins, rat.

Contacts

Медников Дмитрий Сергеевич — аспирант кафедры патологической анатомии, Волгоградский государственный медицинский университет, e-mail: mednikov1988@gmail.com